Enantioselective Determination of R-Clenbuterol Using an Enantioselective, Potentiometric Membrane Electrode Based on a β-Cyclodextrin Derivative

Abstract

An enantioselective, potentiometric membrane electrode based on 2-hydroxy-3-trimethylammoniopropyl-β-cyclodextrin (as its chloride salt) physically immobilized in carbon paste was proposed for the enantioanalysis of R-Clenbuterol. The linear concentration range was between 10−6 and 10−3 mol/Lwith a detection limit of 2.99×10−7 mol/L. R-Clenbuterol was recovered from synthetic as well as from serum samples with average recoveries higher than 99.10%.