Abstract
The first non-enzymatic desymmetrization of prochiral allenic diols via cooperative binary catalysis of Pd(OAc)2 and (R)-STRIP has been reported. This method allows easy access to a series of optically active disubstituted dihydrofurans through palladium mediated 5-endo-trig cyclizations of allenic alcohol with high yields and good to excellent enantioselectivity. A broad substrate scope has been demonstrated.
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