Abstract
New bifunctional atropisomeric thioureas 1 were synthesised and tested as both a mixture of diastereomers (a R/a S)-( R, R)- 1 and as single diastereomers (a R)-( R, R)- 1 and (a R)-( S, S)- 1, in the organocatalysed, enantioselective, cyanosilylation of a range of aldehydes (aromatic and aliphatic). Moderate enantiomeric excesses (up to 69% ee) and quantitative yields were obtained. The best results were achieved using a mixture of thiourea diastereomers (a R/a S)-( R, R)- 1 instead of the single diastereomers alone.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
