Abstract
AbstractEnantioselective transition metal‐catalyzed C−H alkylation emerges as one of the most atom‐ and step‐economical routes to chiral quaternary carbons, while big challenges still remain with acyl C−H alkylations. Herein, we use a Ni−Al bimetallic catalyst to facilitate a highly regioselective and highly enantioselective C−H alkylation of formamides with alkenes, constructing various oxindoles bearing a chiral quaternary carbon in up to 94 % yield and up to 95 % ee.
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