Abstract
AbstractAn asymmetric decarboxylative Mannich reaction of phosphonate sultam‐ketimines with malonic acid half esters is developed enabled by saccharide‐derived bifunctional amino thiourea catalysis. This protocol provides access to a broad range of α‐amino‐β‐carboxylic phosphonates featuring the N,P‐containing tetrasubstituted stereocenters with 78–99% ee. Further synthetic derivatizations could allow the introduction of amide, alcohol, and azetidine scaffolds to the core structures.magnified image
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