Abstract
AbstractA general modular enantioselective synthetic approach to the C(7)–C(18) and the C(7)–C(20) fragment belonging to E‐492, actinofuranone A, and JBIR‐108 was developed. The crucial synthetic step relies on highly enantioselective crotylboration of aldehydes catalyzed by a chiral TRIP PA giving rise to highly enantioenriched terminal alkenes (86 and 88 % ee on the preparative scale). The alkenes were subsequently converted into the title products. Further important synthetic steps included Ru‐catalyzed alkene cross‐metathesis and Suzuki coupling reactions. The approach consists of five synthetic steps starting from easily available aldehydes and other reaction partners.
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