Abstract
The crucial role played by compounds bearing amide functions, not only in biological processes but also in several fields of chemistry, life polymers and material sciences, has brought about many significant discoveries and innovative approaches for their chemical synthesis. Indeed, a plethora of strategies has been developed to reach such moieties. Amides within chiral molecules are often associated with biological activity especially in life sciences and medicinal chemistry. In most of these cases, their synthesis requires extensive rethinking methodologies. In the very last years (2019–2020), enantioselective C-H functionalization has appeared as a straightforward alternative to reach chiral amides. Therein, an overview on these transformations within this timeframe is going to be given.
Highlights
AmidesAmides are are ubiquitous ubiquitous and and one one of of the the most most important importantfunctional functionalgroups groupsin inorganic, organic, medicinal, coordination coordinationand andnatural naturalproducts productschemistries, chemistries,and andin inthe thefields fieldsof of polymers, polymers, medicinal, material and life sciences [1,2].material [1,2]
C-H functionalization strategies, reemerged as valuable approaches for the construction of amide functions. These cently emerged as valuable approaches for the construction of amide functions
A major breakthrough in C-H amidation reactions was the introduction by Chang in points: 2015Aofmajor dioxazolones 1 as acylnitrene precursors
Summary
Amides are are ubiquitous ubiquitous and and one one of of the the most most important importantfunctional functionalgroups groupsin inorganic, organic, medicinal, coordination coordinationand andnatural naturalproducts productschemistries, chemistries,and andin inthe thefields fieldsof of polymers, polymers, medicinal, material and life sciences [1,2]. If several several efforts effortshave havebeen beendevoted devotedtotofinding findingnew newpractical practisynthetic methods to allow their preparation through less conventional ways (i.e., avoiding cal synthetic methods to allow their preparation through less conventional ways (i.e., amine-carboxylic acid couplings with activating agents) [3,4], the[3,4], development of more avoiding amine-carboxylic acid couplings with activating agents) the development “direct” This context, and following the opment of C-H strategies, C-H amidation reactions have have only only recently development of functionalization. A major breakthrough in C-H amidation reactions was the introduction by Chang in points: 2015Aofmajor dioxazolones 1 as acylnitrene precursors [5]. The acylnitrene transfer usually occurs under mild conditions (Scheme 2) [6,7]. Dations reported to date involve the use of dioxazolone as acylnitrene precursors. Cl unexpensive metals (Rh and Ir), the use of abundant, less toxic and cheap first row metal
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
