Abstract
A chloro-containing chiral β-amino alcohol (S)-2-amino-3-(2-chlorophenyl)-1,1-diphenyl-1-propanol ( 1) was prepared from the related amino acid, which was synthesized via malonic ester method. As a catalyst for the enantioselective borane reduction of prochiral ketones, 1 is better than those that have a similar structure but have no halogen atom in the molecule.
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