Abstract
An efficient, and high enantioselective one-pot reaction for ChKRED20 (Ketoreductase20 from Chryseobacterium sp. CA49) for the conversion of thiols and unsaturated α, β-carbonyl compounds into γ-hydroxy sulfides was proposed. The reaction is carried out in water phase, where spontaneous thio-Michael addition is sufficient to provide substrates for enzyme reaction. The effects of aromatic thiophenol substituents on the biocatalytic process were investigated by molecular docking simulations. Eighteen γ-hydroxy sulfides of R-alcohols can be obtained by this green and sustainable approach with high enantioselectivity.
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