Abstract
AbstractA facile and direct method for the construction of enantioenriched α‐arylated quaternary β‐ketoamides was developed. By employing a chiral bifunctional thiourea‐tertiary amine as catalyst, enantioselective α‐arylation of cyclic β‐ketoamides with a quinone monoimine proceeded smoothly to afford various α‐arylated quaternary β‐ketoamides in good yields (up to 97%) with moderate to good enantioselectivities (up to 85% ee). Generally, benzo six‐membered cyclic β‐ketoamides exhibited better enantioselection than benzo five‐membered cyclic β‐ketoamides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.