Abstract
We had synthesized a series of β-hydroxy sulfonamides D-glucosamine and applied them as ligands in the titanium tetraisopropoxide-promoted enantioselective addition of phenylacetylene and hexyne-1 to benzaldehyde and selected aromatic and aliphatic aldehydes. The N-3,5-bis(ditrifluoromethyl)benzenesulfonamido-D-glucosamine derivative performed best and we choose it as the most efficient ligand for the addition of phenylacetylene and hexyne-1 to aldehydes. High enantiomeric excesses, up to 96%, were obtained for some aromatic aldehydes. Keywords: Aldehydes, D-glucosamine, dialkylzinc, enantioselective, hexyne-1, phenylacetylene.
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