Abstract
Lewis acid-mediated reaction of the titanium enolate arising from ( S)- N-acetyl-4-isopropyl-1,3-thiazolidine-2-thione with dimethyl acetals furnishes β-methoxy carboxyl adducts in good yields and stereoselectivities. The adducts can be, in turn, transformed into a wide range of enantiopure α-unsubstituted β-methoxy carboxyl derivatives in excellent yields.
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