Abstract
AbstractThe enantiomers of eight axially chiral biaryls were separated by chiral HPLC. On‐column enantiomerization of 1‐(o‐tolyl)naphthalene and 2‐cyclohexyl‐2′‐dimethylaminobiphenyl was observed between 10 °C and 35 °C, generating characteristic HPLC elution profiles with a plateau between the resolved enantiomer peaks. Computer simulation of the experimentally obtained chromatograms allowed determination of the Gibbs free energies of activation, ΔG≠, as 93.2 kJ/mol and 88.4 kJ/mol, respectively.
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