Abstract
Four chiral aromatic amino alcohol drugs were separated by TLC on a general-purpose silica gel plate with ammonium-D-10-camphorsulfonate (CSA) as chiral ion-interaction agent. The chiral aromatic amino alcohols are all of pharmacological importance as β-adrenergic blockers. The influence of eluent composition, temperature and concentration of CSA on the chiral separation is discussed. It is found that the temperature is also one of the important parameters to be varied for optimum separation in ion-pair chiral resolution. Among four drugs, three enantiomeric drugs were resolved at lower temperature (5°C). In this study, analytical reagent grade methanol and dichlormethane can be directly used as mobile phase without using molecular sieve before use.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
