Abstract
The analytical separation of enantiomers by capillary gas chromatography on chiral stationary phases (CSPs) is reviewed. Inherent principles and methodological advances are described. Three principal CSPs tailored for hydrogen bonding, coordination and inclusion are currently employed. Cyclodextrin derivatives have proved to be the most versatile and universal CSPs in gas chromatography. Anchoring the CSPs to a polysiloxane backbone leads to Chirasil-type stationary phases with improved temperature stability, efficiency and lifetimes. Immobilization of Chirasil-type stationary phases allows enantiomer separations also in capillary supercritical fluid chromatography and capillary electrochromatography. Thermodynamic parameters of enantioselectivity in gas chromatography, kinetic studies of enantiomerization and methods of enantiomer labelling are discussed.
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