Abstract
AbstractWe report the enantiodivergent reaction of ketimines derived from α‐ketoesters with malononitriles using a single chiral source. The reactions using an 8‐quinolinesulfonyl cinchona alkaloid catalyst in the presence and absence of Et2Zn gave both enantiomers in high yields with high enantioselectivities (53∼99% yield, 99:1∼3:97 er). The obtained malononitrile‐derived α‐amino acids were converted into various optically active compounds. A reaction mechanism is proposed to explain the observed enantiodivergency.magnified image
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