Enantiodiscrimination and Enantiocontrol of Neutral and Cationic PtII Complexes Bearing the Tropos Biphep Ligand: Application to Asymmetric Lewis Acid Catalysis

Abstract

The stereochemically stable, enantiopure biphep–Pt complexes can be employed as an atropos asymmetric catalyst at 50 °C or below. Both enantiomeric forms of this complex can be obtained by using either the chiral diamine (R)-dabn or its diamide (R)-dabnTf followed by chirally controlled formation of the single biphep–Pt enantiomer at higher (>60 °C) temperatures (see scheme; Tf=trifluoromethanesulfonate).