Enantioanalysis of S-Ketoprofen Using Enantioselective, Potentiometric Membrane Electrodes

Abstract

Maltodextrins with different dextrose equivalent (DE) values (maltodextrin I: DE 4.0–7.0; maltodextrin II: DE 13.0–17.0; maltodextrin III: DE 16.5–19.5) were used for the design of three enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of S-ketoprofen. The linear concentration ranges for the proposed electrodes were 10−10 to 10−8, 10−9 to 10−5, and 10−10 to 10−7 mol/L, with slopes of 58.0, 58.67, and 58.93 mV/decades of concentration and limits of detection of 1.49 × 10−8, 2.43 × 10−8, and 4.19 × 10−11 mol/L for EPMEs based on maltodextrin I, II, and III, respectively. The EPMEs showed high reliability and effectiveness for the enantioanalysis of S-ketoprofen raw material and its pharmaceutical formulations.