Abstract
Two-step modifications of the Raney nickel were examined for the enantio-differentiating hydrogenation of methyl acetoacetate. Among the two-step modifications attempted in this study, the combination of ‘pre-modification with disodium tartrate and NaBr in water’ and ‘in-situ modification with tartaric acid’ resulted in the highest optical yield (84%). This modification process is a greener process than the conventional one carried out under weakly acidic conditions, because this process generated almost no Ni2+ ions. The pre-modification with the tartrate and NaBr preferentially eliminated Al3+ from the Raney nickel surface.
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