Enantio‐ and Regiocontrolled Synthesis of a Central Ionophoric Antibiotic Building Block by Sequential Opening of Two Epoxide Rings with Cuprate Reagents

Abstract

The sequential opening of two vicinal epoxide groups by cuprate reagents in one step is the key reaction in the synthesis of the stereotetrads 1 and 2. D-Mannitol serves as educt for both compounds, which are contained in several ionophoric antibiotics.