Abstract

AbstractThe asymmetric vinylogous Mukaiyama aldol reaction between α‐keto phosphonate and 2‐(trimethylsilyloxy)furan was performed by using bis(oxazoline)‐copper complexes as the catalyst and 2,2,2‐trifluoroethanol as additive in dichloromethane. The present method is highly tolerable for functionalized α‐keto phosphonates and enabled us to obtain the corresponding 3‐ and 4‐substituted benzyl‐functionalized tertiary α‐hydroxy phosphonates in high yields (up to 86%) as well as high enantiostereoselectivities (up to 98% ee) and diastereoselectivities (up to 99:1, anti‐selective).

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.