Abstract
A new enantio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines through a multicomponent approach has been developed, using highly reactive pyrrolines 4 as preformed cyclic imines. The pyrrolidines obtained using protected aspartic acid as acid component in the Ugi condensation have been transformed into two epimeric bicyclic lactones 18 , 19 , which may find an application as external reverse turn inducers.
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