Abstract
AbstractEnamine N-oxides act as a chemical linchpin bridging two bioorthogonal associative and dissociative reactions. This article describes the design of enamine N-oxides, their synthesis through the retro-Cope elimination reaction, the use of solvent, hyperconjugation, strain, and rehybridization effects to achieve bioorthogonal reactivity, and their rapid reductive cleavage with diboron reagents. The coordinated assembly and disassembly of the enamine N-oxide motif constitutes a powerful chemical operation that enables the attachment and detachment of small molecules from biomacromolecules in a biological setting.1 Introduction2 Background3 General Access to Linear Enamine N-Oxides4 Strain-Promoted Hydroamination Reaction5 Electronically Activated Alkynes6 Chemically Revertible Reactions7 Conclusion
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
