Abstract
The present study evaluated whether enalaprilat (the active form of enalapril, an angiotensin-converting enzyme inhibitor) activates B<sub>1</sub> receptors. We observed that the levels of B<sub>1</sub> receptor mRNA and protein expression were upregulated in the kidneys of diabetic rats. Bradykinin (BK)-induced renal vasodilation decreased in isolated perfused kidneys of diabetic rats, but des-Arg<sup>9</sup>-BK-induced renal vasodilation increased. Enalaprilat also produced vasodilation in the isolated perfused kidneys of control and diabetic rats. The response to des-Arg<sup>9</sup>-BK or enalaprilat was blocked by Lys-(des-Arg<sup>9</sup>, Leu<sup>8</sup>)-BK (a B<sub>1</sub> receptor antagonist) and N-nitro-L-arginine methyl ester (an inhibitor of nitric oxide synthase). These results suggest that enalaprilat activates B<sub>1</sub> receptors and stimulates the production of nitric oxide in the kidneys of both control and diabetic rats.
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