En Face and Volumetric Comparison of Hypertransmission Defects Evaluated by Cirrus and Spectralis Optical Coherence Tomography

Abstract

PurposeTo evaluate and compare en face and 3-dimensional (D) properties of hypertransmission defects (HTDs) between different optical coherence tomography (OCT) devices using OCT volumes and reconstructed en face images. SettingsComparative diagnostic evaluation study. MethodsThirty eyes with dry age-related macular degeneration (AMD) that underwent dense OCT macular volume scans with both the Spectralis (97 B-scans/volume; 2,910 B-scans in total) and Cirrus OCT (128 B-scans/volume; 3,840 B-scans in total) from AMISH EYE STUDY cohort were included in this analysis. HTD regions were labeled on each B-scan and reconstructed into en face and 3-D volume images. Properties of HTD volume were compared between the two devices. ResultsQualitative score of en face images for HTD was higher for the Cirrus compared to the Spectralis (P < 0.01). The quality of Spectralis en face images improved after preprocessing and reconstruction. The 2-D HTD area on en face obtained from 2-D projections of 3-D volume did not differ between devices (P = 0.478; ICC 0.998; Jaccard index 0.721 ± 0.086). There was no difference in the number, volume, PALs, and surface areas of HTDs between devices in the volumetric analysis (all P ≥ 0.090). The signal intensity of HTD normalized by the mean choroidal signal intensity did not differ between devices (P = 0.861). ConclusionsThe visualization of HTD on en face images from Spectralis OCT could be enhanced through image processing. The equivalence in 3-D HTD parameters between the two devices suggests interchangeability for assessing these lesions in AMD.