En Az İki Yıllık İyileşme Dönemi Ardından Allojenik Kök Hücre Nakli Hastalarında Kısa-Form 36 Kullanılarak Sağlıkla İlgili Yaşam Kalitesinin Değerlendirilmesi: Bir Kesitsel Gözlem Çalışması

Abstract

Objective: The use of allogeneic stem cell transplantation (allo-SCT) is increasing and patients are facing physical and mental problems during and after this process. In this study, it was aimed to evaluate the quality of life (QoL) of the patients after at least two or more years from allo-SCT. Material and Methods: 51 transplant patients (TxPs) and 54 healthy controls included in the study. Participants were asked to fill Short Form-36 survey which evaluates QoL in eight main domains. Comparison between TxPs and healthy controls, correlation analyses between remission duration and well being, ROC analysis to find a cut-off value for returning to healthy days were performed. Results: TxPs reported worse QoL than healthy controls. In terms of sex only mental health domain was significantly different where female pariticipants showed better results (p=0.01). Acute or chronic graft versus host disease were not found to have an effect on QoL (p>0.05). Relapsed disease formation had a reducing effect in QoL. Transplant related complications, cytomegalovirus reactivation, conditioning regimen type did not show statistically significant effect on QoL. As the results of the ROC analyses, post-transplant 46th month is found to be a turning point for recovery to healthy status with 68.6% sensitivity and 62.5% spesificity when patients start to realize they regain their health. Conclusion: Allo-SCT has negative effects on patients' physical and social life. In this study it was found that patients start to report similar results to healthy controls in health change approximately after two years from transplantation and the negative effects of transplant were almost completely ceased by 3.5 years.