Abstract
Nasal administration has many advantages over nasal, parenteral or oral administration. Some drugs are ineffective when administered orally due to absorption and first pass metabolism. Therefore, if the aqueous solubility problem can be overcome, the intranasal route will be an alternative method for administration. In this study, emulsion formulation was proposed as a new approach in order to increase the duration of the indomethacin-xylometazoline hydrochloride combination in the nose. The pH value of F1 and F2 emulsions were determined 9.4 and as 5.6 respectively. The particle size of F1 and F2 formulations were found to be 136.8±24 nm and 269.5±66 nm respectively. Formulation of o/w emulsion IND and XYL may be considered as an alternative to iv and po administration. This administration of drugs may be delivery to achieve rapid onset of its pharmacological effect.
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