Abstract
We assessed the behaviour of encapsulated oil-in-water emulsions in alginate beads under dynamic digestion conditions to test their suitability for ileal brake activation. A dynamic gastrointestinal digestion system (DIDGI) was used with three consecutive compartments simulating the stomach, duodenum and distal small intestine. Digestive media were collected periodically to follow lipolysis, as well as the solubilisation of absorbable lipid species in mixed micelles. Free emulsions (i.e., non-encapsulated) in absence or presence of empty alginate beads were used as controls.In the free emulsions lipolysis occurred rapidly with micellar solubilisation not rate limiting, which indicates proximal digestion and absorption. Encapsulation of emulsions in calcium-alginate beads delayed lipolysis typically for 3 h by diffusion limitation, after which most probably mechanical disintegration took place. Our findings do not only increase the understanding of the dynamics of lipid digestion, but also directly link to the design of encapsulates (size and mesh size) for long-term weight management strategies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
