Abstract
Improved outcome in the treatment of childhood cancer results not only from more aggressive and tailored cancer-directed therapy, but also from improved supportive therapy and treatment of life-threatening infectious complications. Prompt and aggressive intervention with empiric antibiotics has reduced mortality in this group of patients. Physical examination, blood tests, and blood cultures must be performed, and antibiotic therapy must be administered as soon as possible. Beta-lactam monotherapy, such as piperacillin-tazobactam or cefepime, may be an appropriate empiric therapy of choice for all clinically stable patients with neutropenic fever. An anti-pseudomonal beta-lactam antibiotic plus gentamicin is recommended for patients with systemic compromise.
Highlights
Abstract tion and treatment of septicemia in the child with cancer remains a very important issue for the specialist physician.[6]
An l anti-pseudomonal beta-lactam antibiotic plus ia gentamicin is recommended for patients with systemic compromise
Merc Introduction m The recent advances and improved outcome o in the treatment of childhood cancer observed over the last decades result from more
Summary
2012 Improved outcome in the treatment of child- from patients with nosocomial blood stream Licensee PAGEPress, Italy hood cancer results from more aggres- infections. Infections due to gram- Pediatric Reports 2012; 4:e2 sive and tailored cancer-directed therapy, but positive organisms have become increasingly doi:10.4081/pr.2012.e2 from improved supportive therapy and treatment of life-threatening infectious complicaly tions.
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