Emphasizing the Mucoadhesive Buccal Drug Delivery System - An Unique Novel Drug Delivery System of the Modern Era

Abstract

With the current emergence of Novel Drug Delivery Systems, mucoadhesive drug delivery systems march outs its significance as a unique novel drug delivery system in the present scenario. The mucosal or mucoadhesive drug delivery system plays a key role as a innovative drug delivery system in the field of Novel Drug Delivery Systems. The term mucoadhesion in a simplier manner signifies the adhesion of two materials with each other where one of the material is the mucosal surface. Certain investigations are on progress to find out an alternative route which can bypass hepatic metabolism, reduce dose frequencies and prolong the drug action. In those cases, delivery of drugs through buccal cavity can be brought up into the real picture. The dosage forms of mucoadhesive drug delivery system includes solids, semisolids and transparent drug loaded films. This when comes into contact with the buccal mucous membrane, drug tends to release at a sustained and controlled manner through the blood capillaries associated in the buccal cavity assuring maximum bioavailibility and thereby increases the ease of drug administration, bypasses hepatic portal systems and gastrointestinal tract, increase in therapeutic efficacy, improved patient compliance and reduction in dose frequencies. With the influx of a large number of new drug molecules due to drug discovery, mucoadhesive drug delivery will play an even more important role in delivering these molecules.