Abstract
Late-life depression (LLD) is a distinct clinical entity which has been estimated to affect 8-16% of elderly patients. Its disease burden is considerable with effects on mortality, development of dementia, functional status, and healthcare utilization. Research has established functional magnetic resonance imaging (fMRI) markers as reliable predictors of treatment in response in LLD, including differential activity and connectivity between various neural structures and networks. However, an underexplored area of previous fMRI studies is whether neural activity during affective tasks may be associated with treatment response in LLD.
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