Abstract
Parkinson's disease is one of the most common neurodegenerative diseases, which affects more than 1% of the world's population, is over 65 years old, and the incidence rate can double by 2030. This pathology is accompanied by both motor and non-motor manifestations (NMM). One of the frequent types of affective disorders in patients with PD is depression. Depression can worsen both the motor and social activity of patients with PD. Understanding the factors associated with depressive symptoms contributes to early detection and timely treatment. In a number of studies, depression and anxiety are recognized as a major factor in the poor quality of life of patients with PD. Aim of the research. To study the features of emotional disorders in patients with Parkinson's disease (PD) and autoimmune thyroiditis (AIT). Materials and methods . 109 patients with PD at the age from 47 to 75 years were examined. The main group of patients consisted of ІА and ІB subgroups, control group - ІІА and subgroups IIB. Conducted general clinical and neurological examination, assessment of motor functions using the unified PD scores (UPDRS), neuropsychological testing (Becky Depression Rating Scale (BDI), Hamilton Alarm Scale (HARS), PDQ-39 quality of life assessment, statistical analysis with program Statistica 6.0. Results. The study showed the presence of depression in 84 patients with PD, which is 77.1%, and anxiety disorders in 73 patients, respectively 67.0%. The analysis of the depression and anxiety index in the dynamics showed a statistically significant difference in the subgroups ІА and ІB. There was a strong statistically significant direct correlation between the scores for the detection of affective disorders and the patient's quality of life indicator (PDQ-39) during the initial examination and a year later in subgroups IA and IB. Conclusions. There was a statistically significant difference in affective disorders in dynamics in patients with PD and AIT. The influence of the level of anxiety and depression on the quality of life of patients with PD and AIT was revealed, which indicates a high medico-social significance of these disorders
Highlights
ІІБ підгрупаПорівнюючи показники тривоги ІБ та ІІБ підгруп при первинному огляді та через рік, виявлено статистично значущу різницю (U=340,5, р=0,03 та U=338,0, р=0,028 відповідно)
Neuroinfection is a worldwide problem, an important cause of morbidity and mortality in the world and in Ukraine [1, 2]
Viral infections are the main cause of meningitis and meningoencephalitis worldwide
Summary
Порівнюючи показники тривоги ІБ та ІІБ підгруп при первинному огляді та через рік, виявлено статистично значущу різницю (U=340,5, р=0,03 та U=338,0, р=0,028 відповідно). Показники депресії та тривоги у пацієнтів із ХП та АІТ через рік представлені у табл. 4. Таблиця 3 Показники депресії та тривоги у пацієнтів із ХП та АІТ при первинному огляді
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