Abstract
Five-month old male New Zealand white rabbits, weighing (2.0±0.2) kg, were purchased from Medical Experimental Animal Centre of Sun Yat-Sen University in China. Animal welfare assurance: 2001A033. Rabbits were randomly divided into 4 groups of 8: control, atherosclerosis, emodin and fenofibrate. The control rabbits were fed on a regular diet, while all other rabbits were fed on diet including 1% cholesterol and 5% fat for 10 weeks. Each rabbit was fed 135 g to150 g food per day and had free access to water. During the last 4 weeks of diet, the rabbits in emodin and fenofibrate groups were given emodin (10 mg/kg, Guangzhou Chinese Medicine Company) or fenofibrate (25 mg/kg) orally, each of which was dissolved in 2 ml normal saline. The rabbits in control and atherosclerotic model groups were given 2 ml normal saline at the same time.
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