Emerging trends in miniaturized and microfluidic electrochemical sensing platforms

Abstract

Electrochemical sensing has established a strong presence in diverse areas. The conventional electrochemical sensing approach consumes large sample volumes and reagents and requires bulky potentiostat, macro-electrodes, and other equipment. The synergistic integration of electrochemical sensing systems with miniaturized or microfluidic electrochemical devices and microelectrodes in a single platform provides rapid analysis with a disposable, reusable, and cost-effective platform for multiplexed point-of-care detections. Such microdevices have created scope for using several materials as electrodes and sensing platforms by using appropriate fabrication techniques. One of the most recent advancements in miniaturized devices includes the integration of automation and Internet of Things to realize fully automated and robust electrochemical microdevices. The review summarizes the emerging trends in fabrication methods of miniaturized and microfluidic devices, their multiple applications in real-time, integration of Internet of Things, automation, identifying research gaps with strategies for bridging these gaps, future outlook, and recent approaches to intelligent electrochemical sensing.