Abstract
This review meticulously examines thesynthesis techniques for 1,3,4-thiadiazole derivatives, focusing on cyclization, condensation reactionsand functional group transformations. It enhances the understanding of these chemical methods that recrucial for tailoring derivativeproperties and functionalities. This study is considered to bevital for researchers, detailing established effects such asantioxidant, antimicrobialand anticancer activities, and revealing emerging pharmacological potentials such as neuroprotective, antiviraland antidiabetic properties. It also discussesthe molecular mechanisms underlying these effects. In addition, this article covers structure-activity relationship studies and computational modelling that areessential for designing potent, selective 1,3,4-thiadiazole compounds. This work lays a foundation for future research and targeted therapeutic development.
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