Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity.

Chunyuan Zhao,Xiuzhi Jia,Wei Zhao

doi:10.3389/fimmu.2021.687102

Chunyuan Zhao, Xiuzhi Jia + Show 1 more

Open Access

https://doi.org/10.3389/fimmu.2021.687102

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Journal: Frontiers in immunology	Publication Date: Jun 10, 2021
Citations: 19	License type: CC BY 4.0

Affiliation: Shandong University

Abstract

The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. The E3 ubiquitin ligases encoded by these genes possess important roles in controlling the intensity of innate immune responses. In this review, we discuss the E3 ubiquitin ligases encoded within the MHC-I region, highlight their regulatory roles in innate immunity, and outline their potential functions in infection, inflammatory and autoimmune diseases.

Highlights

Innate immunity is the first line of defense against invading pathogens and cancers
Increasing evidences indicate that the major histocompatibility complex (MHC)-I region encoded E3 ubiquitin ligase genes possess moderate levels of polymorphism, play regulatory roles in innate immune responses (Figure 2), and their expressions are associated with a variety of autoimmune diseases [8]
These MHC-I region genes are related to a variety of inflammatory, viral and autoimmune diseases

Summary

Frontiers in Immunology

Emerging Roles of MHC Class I Region-Encoded E3 Ubiquitin Ligases in Innate Immunity. The major histocompatibility complex (MHC) class I (MHC-I) region contains a multitude of genes relevant to immune response. Multiple E3 ubiquitin ligase genes, including tripartite motif 10 (TRIM10), TRIM15, TRIM26, TRIM27, TRIM31, TRIM38, TRIM39, TRIM40, and RING finger protein 39 (RNF39), are organized in a tight cluster, and an additional two TRIM genes (namely TRIM38 and TRIM27) telomeric of the cluster within the MHC-I region. The E3 ubiquitin ligases encoded by these genes possess important roles in controlling the intensity of innate immune responses. We discuss the E3 ubiquitin ligases encoded within the MHC-I region, highlight their regulatory roles in innate immunity, and outline their potential functions in infection, inflammatory and autoimmune diseases

INTRODUCTION

Findings

CONCLUSION AND PERSPECTIVE