Abstract
Esophageal squamous cell carcinoma (ESCC) is a highly prevalent tumor and is associated with ethnicity, genetics, and dietary intake. Non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been reported as functional regulatory molecules involved in the development of many human cancers, including ESCC. Recently, several ncRNAs have been detected as oncogenes or tumor suppressors in ESCC progression. These ncRNAs influence the expression of specific genes or their associated signaling pathways. Moreover, interactions of ncRNAs are evident in ESCC, as miRNAs regulate the expression of lncRNAs, and further, lncRNAs and circRNAs function as miRNA sponges to compete with the endogenous RNAs. Here, we discuss and summarize the findings of recent investigations into the role of ncRNAs (miRNAs, lncRNAs, and circRNAs) in the development and progression of ESCC and how their interactions regulate ESCC development.
Highlights
Esophageal cancer (EC) is the eighth most prevalent malignant tumor and sixth leading cause of cancer-related death worldwide [1,2]
The occurrence rate of EC varies depending upon geographical location and esophageal squamous cell carcinoma (ESCC) is observed to be the most prevalent type of EC [3]
LncRNA LBX2-AS1 can contribute to the malignant progression of ESCC by promoting tumor migration and epithelial–mesenchymal transition (EMT) [114]
Summary
Esophageal cancer (EC) is the eighth most prevalent malignant tumor and sixth leading cause of cancer-related death worldwide [1,2]. The occurrence rate of EC varies depending upon geographical location and esophageal squamous cell carcinoma (ESCC) is observed to be the most prevalent type of EC [3]. Consistent with other cancers, ESCC is characterized by epigenetic abnormalities and dysregulation in the signaling pathways [3]. Chemotherapy, radio-chemotherapy, and esophagectomy are the predominant therapeutic strategies for ESCC. Non-coding RNAs (ncRNAs) have gained attention as a potential tool for treating different cancers, including ESCC [7,8]. The regulatory ncRNAs are broadly subcategorized into microRNAs (miRNAs, 18–25 nt), small interfering RNAs (siRNAs,
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