Abstract
Near-infrared (NIR)-light-triggered therapy platforms are now considered as a new and exciting possibility for clinical nanomedicine applications. As a promising photothermal agent, polypyrrole (PPy) nanoparticles have been extensively studied for the hyperthermia in cancer therapy due to their strong NIR light photothermal effect and excellent biocompatibility. However, the photothermal application of PPy based nanomaterials is still in its preliminary stage. Developing PPy based multifunctional nanomaterials for cancer treatment in vivo should be the future trend and object for cancer therapy. In this review, the synthesis of PPy nanoparticles and their NIR photothermal conversion performance were first discussed, followed by a summary of the recent progress in the design and implementation on the mulitifunctionalization of PPy or PPy based therapeutic platforms, as well as the introduction of their exciting biomedical applications based on the synergy between the photothermal conversion effect and other stimulative responsibilities.
Highlights
Over the past decades, various environmental-responsive smart polymeric materials have been constantly developed to meet the diverse needs in the biomedical field, especially in the tailor-made design of smart delivery and release systems for the cancer therapy [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]
The combined therapy composed of chemotherapy and photothermal therapy can directly kill the cancer cells by the hyperthermia induced by photothermal agent, and at the same time increase the sensitivity of chemotherapy, resulting in a synergistic enhancement in the therapeutic effects
The hollow microspheres (HMs) generated by a capillary fluidic device have a shell of poly(D,L-lactic-co-glycolic acid) (PLGA) and an aqueous core comprised of vancomycin (Van) and PPy Nanoparticles (PPy NPs)
Summary
Various environmental-responsive smart polymeric materials have been constantly developed to meet the diverse needs in the biomedical field, especially in the tailor-made design of smart delivery and release systems for the cancer therapy [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. The preparation of PPy by chemical oxidation polymerization hadThe been widely investigated in variousoxidation organic solvent and aqueous mediawidely using vascular bed [79]. NPs based on the chemical oxidation devoted to explore more precise synthesis routes and conditions for morphology- and size-controllable polymerization mechanism. NPs can be prepared based oxidative polymerization pyrrole in the aqueous solution. Potential application of PPy NPs in the photothermal ablation therapy
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