Emerging Metabolic and Transcriptomic Signature of PNPLA3‐Associated NASH

Abstract

Non-alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide. About 30% of the adult population in the United States (US) is afflicted with NAFLD. Approximately 20-25% of NAFLD patients have the progressive sub-type of NAFLD that is termed as Non-alcoholic Steatohepatitis (NASH). The cardinal features of NASH on liver histology include steatosis, lobular inflammation, ballooning with or without peri-sinusoidal fibrosis.