Emerging insights into pyrazoline motifs: A comprehensive exploration of biological mechanisms and prospects for future advancements

Abstract

The prevalence of cancer and neurodegenerative diseases, such as Alzheimer's and Parkinson's, continues to rise worldwide, presenting a significant health burden. Despite extensive research efforts, effective treatments for these conditions remain elusive, highlighting the need for novel therapeutic approaches. Pyrazolines have emerged as a highly promising class of heterocyclic compounds in drug discovery. In this comprehensive literature review spanning the last six months, we explore the potential of pyrazoline motifs as a promising category of compounds for drug development targeting several key biological macromolecules, including TMK, AChE, MAO, ErbB, COMT, HDAC, and many more. Our focus is on the latest developments in the drug discovery of pyrazoline-based compounds, emphasizing recent mechanistic studies that have not yet been covered in previous reviews. To ensure the most up-to-date information, we have exclusively incorporated research articles published within the last five years from high-ranked journals. We provide an overview of marketed drugs, including Ibipinabant, Ramifenazone, and Axitinib. Pyrazoline proves to be a promising pharmacophore for developing novel molecules to combat emerging diseases and drug resistance, offering improved biological activity, lower toxicity, and desirable pharmacokinetic properties. This review serves as an invaluable resource for researchers and scientists working on the cutting edge of drug discovery.