Abstract
We know from complete sequencing of three alphaherpesvirus genomes that these large DNA viruses around 70 genes. In many cases little is known of gene function. Features of predicted amino acid sequences have given a number of clues to functions, mostly for enzymes and membrane-associated proteins. Genetic analyzes have very strikingly shown that over 30 genes are dispensable for virus growth in tissue culture. A variety of experimental approaches is giving information on many areas of gene function including control of gene expression, modulation of cell state, DNA replication, virion formation and structure and cell entry mechanisms.
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