Abstract

Parkinson’s disease is a debilitating neurodegenerative disorder characterized by both motor and non-motor symptoms. Less than 10% of cases are known to be directly caused by genetic factors. Extensive research has focused on environmental factors that may influence risk. Metals, pesticides and other occupational and environmental exposures have received significant attention. However, for most individuals, high-dose exposures from these exposures are unlikely. Heterocyclic amines (HCAs) are commonly found in the diet, leading to life-long exposure. HCAs have been extensively examined as carcinogens. However, there is an emergent literature on HCA-induced neurotoxicity. In this chapter, we critically examine the current research on HCA exposure and its possible role in neurodegeneration.KeywordsParkinson’s diseaseHeterocyclic amineDiet

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