Emerging Bioinformatics Methods and Resources in Drug Toxicology.

Abstract

Assessing the drug safety at an early stage of a drug discovery program is a critical issue. With the recent advances in molecular biology and genomic, massive amounts of generated and accumulated data by advanced experimental technologies such as RNA sequencing or proteomics start to be at the disposal of the scientific community. Innovative and adequate bioinformatic methods, tools, and protocols are required to analyze properly these diverse and extensive data sources with the aim to identify key features that are related to toxicity observations. Furthermore, the assessment of drug safety can be performed across multiple scales of complexity from molecular, cellular to phenotypic levels; therefore, the application of network science contributes to a better interpretation of the drug's exposure effect on human health. Here, we review databases containing toxicogenomics and chemical-phenotype information, as well as appropriated bioinformatics approaches that are currently used to analyze such data. Extension to others methods such as dose-responses, time-dependent processes, and text mining is also presented giving an overview of suitable tools available for a best practice of drug safety analysis.