Abstract
Abstract The University of California San Francisco Medical Center Committee on Human Welfare and Experimentation has reviewed 340 applications for research involving human beings during its first two years of operation. The Committee delegated review to three-man ad hoc groups selected on the basis of expertise and objectivity. Seventeen protocols were rejected by at least two ad hoc committees because risk-benefit ratio could not be assessed (seven), because of inadequate precautions (eight) and because of unacceptable risk (two). The decisions of the Committee were on the whole well accepted, ad hoc groups have increasingly adopted the standards defined by the parent Committee, and wide involvement of the faculty in the reviewing process has led to greater recognition of the legal and moral obligations incurred by those who study man.
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