Abstract

Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emergent arthropod-borne viruses that produce outbreaks of acute febrile illness with arthropathy. Despite their different continental origins, CHIKV and MAYV are closely related and are components of the Semliki Forest Complex of the Alphavirus (Togaviridae). MAYV and, more recently, CHIKV, which are both transmitted by Aedes mosquitoes, have resulted in severe public health problems in the Americas, including Brazil. In this review, we present aspects of the pathogenesis, clinical presentation and treatment of febrile illnesses produced by CHIKV and MAYV. We also discuss the epidemiological aspects and effects related to the prophylaxis of infections by both viruses.

Highlights

  • The spread of ribonucleic acid (RNA) viruses has been facilitated by environmental degradation and population growth

  • The structural proteins are encoded by 4,327 nucleotides located at a subgenomic messenger ribonucleic acid that is colinear with the 3′ one-third of the genome, which starts at position 7,498 and excludes the poly (A) tail

  • A Mayaro virus (MAYV) mutant could adapt to anthropophilic mosquito vectors and spread toward northeastern and southeastern Brazil, as well as neighboring countries, which would result in an even more serious public health problem

Read more

Summary

INTRODUCTION

The spread of ribonucleic acid (RNA) viruses has been facilitated by environmental degradation and population growth. Migrations to urban areas and the uncontrolled growth of cities can increase the spread of pathogens. These pathogens transition from a health problem in a restricted area to a worldwide problem[1]. Emerging viruses typically originate in resource-poor settings and without a health surveillance structure. CHIKV and MAYV are able to mutate and/or adapt to new zoonotic cycles and acquire a higher potential for emergency. These arboviruses may emerge as a result of environmental degradation and socio-economic disturbances[6]. Climate changes that interfere with human activities influence the emergence of these pathogens and enhance their geographical spread

GENOME ORGANIZATION AND VIRAL REPLICATION
CHIKUNGUNYA VIRUS
MAYARO VIRUS
LABORATORY DIAGNOSIS
TREATMENT OF PATIENTS AND VACCINES TO PREVENT CHIKV AND MAYV INFECTIONS
Findings
FINAL REMARKS

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.