Abstract
We present single-molecule experimental and computational modeling studies investigating the accessibility and folding landscape of human telomeric overhangs that contain 4-28 repeats of GGGTTA (G-Tract) sequence. These sequences reach physiologically relevant lengths and can accommodate 1-7 G-quadruplex (GQ) structures. Using FRET-PAINT, we probed the distribution of telomeric sites that are accessible to external agents via a short imager strand that is complementary to a G-Tract and transiently binds to sites that are not within a GQ.
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