Abstract
To the Editor: We read with interest the letter by Sarkar et al. on new Vibrio cholerae phages (1). The description of new V. cholerae phages is a welcome tool for epidemiologic studies of this species. Our main concern about their work is the inaccurate picture that is presented of the cholera epidemic in Brazil. Some of the statements made in the final paragraphs are in disagreement with the official epidemiologic records and the characteristics of the Vibrio bacteria that occurred in Brazil during the 1990s epidemic (2). In 1991, the seventh cholera pandemic reached South America by the Pacific coast, spreading to Brazil in the same year (3). In Brazil, the first cholera cases were reported in the Amazon region bordering Peru; within a few months a large number of cholera cases were recorded in states facing the Atlantic Ocean in the northeastern region (2). According to the official figures of the Brazilian Ministry of Health (2), 168,598 cases of cholera caused by a V. cholerae O1 El Tor strain occurred in Brazil from 1991 to 2001. Of these, 155,363 (92.1%) occurred in the northeastern area of the country, with 2,037 deaths. From 2001 to 2003, the number of confirmed cases was 4,756, 734, and 7, respectively. Sarkar et al. (1) indicate that 60,000 cases occurred from 1991 to 2001 in Rio de Janeiro, a city localized in the southeastern region; the official records report only 349 cases. The statement that “since 1993, no cholera cases caused by O1 have been reported” is also perplexing. From 1994 to 2001, the official records report 68,583 cases of cholera in Brazil (51,324 of these in 1994, the second major year of cholera incidence). Are the authors suggesting that this number of cases was caused by non-O1 V. cholerae? The official records state that the cholera epidemic in Brazil was caused by an El Tor O1 strain (4,5).
Highlights
Human adenoviruses are the cause of a wide spectrum acute and chronic diseases
Since Ad7d2 has been associated with 3 military and 3 civilian epidemics and at least 19 deaths in the United States since 1993, the 2002 report voiced concern regarding a shift in the prevalence of U.S adenovirus strains and the need to increase surveillance for adenoviral disease
We present a retrospective study of adenovirus type 7 (Ad7) isolates in Iowa
Summary
Human adenoviruses are the cause of a wide spectrum acute and chronic diseases. The associations of adenovirus with keratoconjunctivitis, upper respiratory tract infections, pneumonia, gastroenteritis, cystitis, and encephalitis have long been recognized. In 2002, Erdman et al [7] reported that 2 emergent genome types of adenovirus type 7 (Ad7) had recently been detected in North American populations. From restriction enzyme studies of 166 archived specimens, the available data suggested that Ad7d2 and Ad7h first appeared in North America in 1993 and 1998, respectively. Both genome types had been associated with epidemics, severe illness, and deaths in populations outside the United States.
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