Abstract
The term group A Streptococcus is considered synonymous for the species Streptococcus pyogenes. We describe an emergent invasive S. dysgalactiae subspecies equisimilis lineage that obtained the group A antigen through a single ancestral recombination event between a group C S. dysgalactiae subsp. equisimilis strain and a group A S. pyogenes strain.
Highlights
The term group A Streptococcus is considered synonymous for the species Streptococcus pyogenes
Active Bacterial Core surveillance (ABCs) identifies invasive infections caused by group A Streptococcus (GAS) without identification of isolates to the species level
Since 2015, when we implemented whole-genome sequence (WGS) as our primary platform for GAS characterization, we have identified rarely occurring non–S. pyogenes isolates through our bioinformatics pipeline automated MLST function rather than previously employed phenotypic testing
Summary
The term group A Streptococcus is considered synonymous for the species Streptococcus pyogenes. Lancefield grouping [7] and MLST (https://pubmlst.org/sdysgalactiae) [6] revealed the 35 isolates were serologically group A and MLST sequence type (ST) 128 (GAS/ST128/SE). Genomic comparison of the 12 gene group A carbohydrate synthetic cluster gacA-L [1] from S. pyogenes with the corresponding regions of the 35 GAS/ST128/SE revealed an upstream crossover point within the S. pyogenes gacE ABC transporter gene and a downstream crossover point within ebsA (Figure 2).
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