Abstract
Currently, Zika virus (ZIKV) is spreading across the world and no ZIKV infection cases have ever been reported in China. Here, we aimed to determine whether ZIKV infection exists in China. Blood samples of 273 healthy individuals were collected from Nanning City, Guangxi Province, China in March 2019. We found that 9.5% (26/273) and 1.8% (5/273) of healthy persons were positive to ZIKV total antibody (IgG and/or IgM) IgM antibody, respectively. All ZIKV positive plasma samples were negative to Dengue virus and West Nile virus. Among the ZIKV antibody positive plasma samples, 65.4% (17/26) exhibited neutralizing activity to ZIKV. Followed up studies showed that none had clinical symptoms of ZIKV infection and oversea experience. Together, our study indicates that endemic ZIKV infections emerge in China, which not only suggested that ZIKV posed a potential threat to public health in China, but also expand the ZIKV epidemic areas in East and Southeast Asia.
Highlights
Zika virus (ZIKV) is a positive single-stranded RNA virus, belonging to mosquito-borne Flavivirus, which was first discovered in Uganda in 1947 from a sentinel febrile rhesus monkey [1,2]
ELISA results showed that 9.5% (26 /273) of healthy human plasma samples were positive to total ZIKV antibodies (IgG and IgM) and 1.8% (5/273) of healthy individuals were ZIKV IgM positive (Fig 1A; Table 1)
ELISA results showed that all 26 ZIKV positive plasma samples were negative to Dengue virus (DENV) and WNV
Summary
Zika virus (ZIKV) is a positive single-stranded RNA virus, belonging to mosquito-borne Flavivirus, which was first discovered in Uganda in 1947 from a sentinel febrile rhesus monkey [1,2]. Adults infected with ZIKV are mostly asymptomatic or exhibited mild fever, but for newborn infants the infection caused severe microcephaly [2,3]. Zika virus infection in China mentioned that ZIKV remained neglected until the outbreak of ZIKV infections in Micronesia in 2007 [4]. ZIKV is spreading around the world and 89 countries have reported ZIKV cases [5]. In South and Southeast Asia, 12 countries have reported ZIKV infections including Bangladesh, Cambodia, India, Indonesia, Laos, Malaysia, Maldives, Myanmar, Philippines, Singapore, Thailand, and Vietnam [5]
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