Abstract
An early increase in outbreaks of norovirus gastroenteritis characterised at the French National Reference Centre occurred this winter season. They were concurrent with an unusual pattern of circulating strains, with three predominant genotypes: the re-emergent variant GII.P4 2009-GII.4 2012 found in 28% of norovirus outbreaks and two new emergent recombinant strains GII.P16-GII.4 2012 and GII.P16-GII.2 never before observed in France, found in 24% and 14% of norovirus outbreaks, respectively.
Highlights
We report an early increase in norovirus (NoV) gastroenteritis outbreaks investigated during this 2016/17 season at the French National Reference Centre for Gastroenteritis Viruses (NRCgev), compared with the previous season (Figure 1)
From week 40 in 2016 to week 3 in 2017, 350 stool samples corresponding to 114 gastroenteritis outbreaks were investigated at the French NRCgev
Phylogenetic analysis showed that all the GII.P4 2009GII.4 2012 strains found in this study clustered with the strain GII.P4 2009-GII.4 2012 (GenBank KF199164) found in Denmark in March 2013 [3], in both the polymerase and capsid regions (Figures 3 and 4)
Summary
Emergence of new recombinant noroviruses GII.p16GII. and GII.p16-GII., France, winter 2016 to 2017. M Bidalot 1 , L Théry 1 , J Kaplon 1 2 , A De Rougemont 1 2 , K Ambert-Balay 1 2 1. Citation style for this article: Bidalot M, Théry L, Kaplon J, De Rougemont A, Ambert-Balay K. An early increase in outbreaks of norovirus gastroenteritis characterised at the French National Reference Centre occurred this winter season. They were concurrent with an unusual pattern of circulating strains, with three predominant genotypes: the re-emergent variant GII.P4 2009-GII.4 2012 found in 28% of norovirus outbreaks and two new emergent recombinant strains GII.P16-GII.4 2012 and GII.P16-GII. never before observed in France, found in 24% and 14% of norovirus outbreaks, respectively. Molecular characterisation and phylogenetic analysis of the strains responsible for these outbreaks showed that three predominant genotypes were co-circulating, including two new emergent recombinant strains never before observed in France
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